Age activator
نویسندگان
چکیده
منابع مشابه
osteoprotegerin and soluble receptor activator of nuclear factor-kappa b ligand in exudative age-related macular degeneration.
calcification and inflammation are among the important cases of exudative age-related macular degeneration (e-armd). the aim of the present study was to elucidate if there is any relationship between serum osteoprotegerin (opg), soluble receptor activator of nuclear factor-kappa b ligand (rank-ligand) and e-armd. in a cross-sectional study, we compared 45 e-armd patients with 45 matched control...
متن کاملAge and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact.
Recombinant tissue-type plasminogen activator (tPA) is the fibrinolytic drug of choice to treat stroke patients. However, a growing body of evidence indicates that besides its beneficial thrombolytic role, tPA can also have a deleterious effect on the ischaemic brain. Although ageing influences stroke incidence, complications and outcome, age-dependent relationships between endogenous tPA and s...
متن کاملAge-specific Cost Effectiveness of Using Intravenous Recombinant Tissue Plasminogen Activator for Treating Acute Ischemic Stroke
INTRODUCTION Studies have demonstrated that intravenous recombinant tissue plasminogen activator (IV rtPA) is a cost-effective treatment for acute ischemic stroke. Age-specific cost effectiveness has not been well examined. This study estimated age-specific incremental cost-effectiveness ratios (ICERs) of IV rtPA treatment versus no IV rtPA. METHODS A Markov model was developed to examine the...
متن کاملValue of soluble Urokinase plasminogen activator receptor over age as a biomarker of impaired myocardial relaxation
BACKGROUND SuPAR is a biomarker that reflects the level of immune activation. As inflammation plays an important role in the ageing process of the cardiovascular system, we hypothesized that suPAR might be a useful predictive biomarker of the ageing heart. METHODS We performed conventional and tissue Doppler echocardiography and measured plasma suPAR levels. RESULTS We studied community adu...
متن کاملEvaluation of an oral telomerase activator for early age-related macular degeneration - a pilot study
PURPOSE Telomere attrition and corresponding cellular senescence of the retinal pigment epithelium contribute to the changes of age-related macular degeneration. Activation of the enzyme telomerase can add telomeric DNA to retinal pigment epithelium chromosomal ends and has been proposed as a treatment for age-related macular degeneration. We report the use of a small molecule, oral telomerase ...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2002
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc729